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Научные статьи
Клинические доказательства
ФАРМАТЕКА № 4 — 2011 Т.Г.Шаповалова, И.М.Борисов, П.Е.Крайнюков, М.М.Шашина, Л.И.Лекарева
Журналъ Акушерства и женскихъ бользней выпуск 1 том LI 2002 - М.А.Репина, Н.Ю.Крылова, Г.В.Митченко, Я.А.Корнилова
Эффективная Фармакотерапия в акушерстве и гинекологии №5 декабрь 2007 Практическая медицина 1 (86) январь 2015 г.П.В. БУДАНОВ, К.М.Н., доцент ММА им. И.М. Сеченова
Вопросы гинекологии, акушерства и перинатологии 2005, Т4 №1 М.А.Репина, Т.М.Корзо, Я.А.Корнилова
Журнал Медународной медицины 2014/Номер 5(10) В. Унзеитиг, В. Дворак, О. Главачкова, Т. Малик, Ю. Новы, А. Стара, А. Скриванек, Ю. Штепан
Доктор.ру ГИНЕКОЛОГИЯ часть1 №9(68),2011 в 2 частях Пестикова Т.Ю., Молодцова Л.Ю, Колбина А.С., Климка Н.Н., Стернин Ю.И.
З.С.Ходжаева, В.М.Сидельникова, П.А.Кирющенков, А.С.Ходжаева Научный центр акушерства, гинекологии и перинатологии (дир. – акад. РАМН В.И.Кулаков), Москва;
Медицинский советник №3 2013 Н.А. Малышева Ю.И. Стернин
Г.В. Таец, Н.К. Артеменко, Н.В. Заславская, К.Л. Артеменко, Г.Ю. Кнорринг, В.В. Таец, Ю.И. Стернин
Научно-практический медицинский журнал "Доктор.ру" (Выпуск №5(49) 2009 г.)

Клинические доказательства

Вобэнзим изучается со времен его создания, т.е. с 60-х годов прошлого века, притом, что и при создании было проведено множество экспериментов и исследований, работы продолжаются и сейчас.

По энзимотерапии есть множество исследований, в том числе – соответствующих требованиям GCP (good clinical practice) – многоцентровых двойных слепых рандомизированные плацебоконтролируемых, т.е. уровень B и C; есть несколько систематических обзоров (мета – анализы), т.е. уровень доказательности A. Ссылки на эти обзоры приведены ниже.

Исследования уровня GCP проводились и на территории Российской Федерации, например, в сосудистой хирургии (РГМУ, каф. В.С. Савельева) и детской ревматологии (НИИ Ревматологии РАМН). По «ВОБЭНЗИМУ» защищено более 100 кандидатских и 30-ти докторских диссертаций, публикации в реферируемых журналах – более 300.

Ссылки на исследования, цитируемые на авторитетных сайтах:

"medscape.com": Закрытый источник

* Klein G; Kullich W; Schnitker J; Schwann H. Efficacy and tolerance of an oral enzyme combination in painful osteoarthritis of the hip. A double-blind, randomised study comparing oral enzymes with non-steroidal antiinflammatory drugs. Clin Exp Rheumatol. 2006; 24(l):25-30 [http://reference.medscape.com/medline/abstract/16539815] (ISSN: 0392-856X)

* Tilscher H; Keusch R; Neumann K. Results of a double-blind, randomized comparative study of Wobenzym vs placebo in patients with cervical syndrome. Wien Med Wochenschr. 1996; 146(5):91-5 [http://reference.medscape.com/medline/abstract/8686328] (ISSN: 0043-5341)

* Singer F; Oberleitner H/.Drug therapy of activated arthrosis. On the effectiveness of an enzyme mixture versus diclofenac. Wien Med Wochenschr. 1996; 146(3):55-8 [http://reference.medscape.com/medline/abstract/8867274] (ISSN: 0043-5341)

* Rammer E; Friedrich F. Enzyme therapy in treatment of mastopathy. A randomized double-blind clinical study/Wien Klin Wochenschr. 1996; 108(6):180-3 [http://reference.medscape.com/medline/abstract/8650928] (ISSN: 0043-5325)

* Lanchava N; Nemsadze K; Chkhaidze I; Kandelaki E; Nareklishvili N. Wobenzym in treatment of recurrent obstructive bronchitis in children.//Georgian Med News. 2005; (127):50-3 [http://reference.medscape.com/medline/abstract/16308444] (ISSN: 1512-0112)

* Minaev SV; Obozin VS; Barnash GM; Obedin AN. The influence of enzymes on adhesive processes in the abdominal cavity.//Eur J Pediatr Surg. 2009; 19(6):380-3 [http://reference.medscape.com/medline/abstract/19866411] (ISSN: 1439-359X)

* Suzdal'nitskij RS; Levando VA; Emel'ianov BA; Sokolov laA. The adaptational properties and immunoregulatory action of a preparation of proteolytic enzymes in experimental stress. Zh Mikrobiol Epidemiol Immunobiol. 1999; (5):103-6 [http://reference.medscape.com/medline/abstract/10852034] (ISSN: 0372-9311)

* Neverov VA; Klimov AV. The pathogenetic basis for and clinical use of systemic enzyme therapy in traumatology and orthopedics.// Vestn Khir Im I I Grek. 1999; 158(l):41-4 [http://reference.medscape.com/medline/abstract/10491833] (ISSN: 0042-4625)

* Gal P; Teel F; Skotakova J; Mach V. Systemic enzyme therapy in the treatment of supracondylar fractures of the humerus in children.//Rozhl Chir. 1998; 77(12):574-6 [http://reference.medscape.com/medline/abstract/10081327] (ISSN: 0035-9351)

* Szczurko 0; Cooley K; Mills EJ; Zhou Q; Perri D; Seely D. Naturopathic treatment of rotator cuff

tendinitis among Canadian postal workers: a randomized controlled trial.//Arthritis Rheum. 2009; 61(8):1037-45 [http://reference.medscape.com/medline/abstract/19644905] (ISSN: 0004-3591)

"Cochrane base":

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* Marshall M, Kleine M-W. WIRKSAMKEIT UND VERTRAGLICHKEIT EINER ORALEN ENZYMTHERAPIE BEI DER SCHMERZHAFTEN AKUTEN THROMBOPHLEBITIS SUPERFICIALIS. (Efficacy and tolerability of an oral enzyme therapy in the treatment of painful acute superficial thrombophlebitis.) [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/816/CN-00406816/frame.html]

* May C, Smola M, Ruda C, Scharnagl E. Randomized open controlled clinical study on the efficacy and tolerance of an oral enzyme preparation in lymphadenectomy patients. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/662/CN-00425662/frame.html]

* Koshkin VM, Kirienko Al. Systemic enzyme therapy in the treatment of acute thrombosis of superficial veins in the lower extremities and postthrombophlebitic disease. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/060/CIM-00443060/frame.html]

* Tilscher H, Keusch R, Neumann K. Ergebnisse einer doppelblinden, randomisierten Vergleichsstudie Wobenzym-Plazebo bei Patienten mit Zervikalsyndrom.(Results of a double-blind, randomized comparative study of Wobenzym-placebo in patients with cervical syndrome). [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/756/CN-00125756/frame.html]

* Alban S, Franz M E, Franz G. Influence on blood coagulation after oral application of wobenzym-phyto tablets containing bromelain, papain and rutin. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/649/CN-00334649/frame.html]

* Singer F, Oberleitner H Ein Beitrag zur medikamenti^sen Therapie der aktivierten Arthrose. Zur Effektivitet eines Enzymgemisches versus Diclofenac. (Drug therapy of activated arthrosis. On the effectiveness of an enzyme mixture versus diclofenac.) [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/837/CN-00131837/frame.html]

* Rammer E, Friedrich F. Enzyme therapy in mastopathy. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/814/CN-00172814/frame.html]

* Singer F, Oberleitner H. Osteoarthritis of the knee - Effectiveness of enzymes vs diclofenac in acute phase of osteoarthritis of the knee - A randomized, double blind controlled study. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/430/CN-00173430/frame.html]

* Tilscher H, Keusch R, Neumann K. Results of a double-blind randomized, comparative study of Wobenzymregistered trade mark - Placebo by patients with cervical syndrome^ [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/814/CN-00173814/frame.html]

* Korpan Ml, Fialka V. Wobenzym- und Diuretikatherapie beim Lymphi^dem nach Mammaoperation. (Wobenzyme and diuretic therapy in lymphedema after breast operation). [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/531/CN-00124531/frame.html]

* Zavadova E, Desser L, MohrT. Stimulation of reactive oxygen species production and cytotoxicity in human neutrophils in vitro and after oral administration of a polyenzyme preparation. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/850/CN-00117850/frame.html]

* Korpan Ml, Fialka V. Wobenzymregistered trade mark and diuretics therapy with lymph edema after breast operation. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/406/CN- 00171406/frame, html]

* Hoernecke R, Doenicke A. PERIOPERATIVE ENZYMTHERAPIE. EINE SINNVOLLE ERGANZUNG ZUR POSTOPERATIVEN SCHMERZTHERAPIE. (Adjuvant treatment of pain with a perioperatively administered enzyme compound.)[http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/469/CN-00180469/frame.html]

* DitmarF-W, Luh W. Treatment of fibrocystic mastopathy with hydrolytic enzymes, [http://www.mrw. interscience, wiley. com/cochrane/clcentral/articles/911/CN- 00179911/frame.html]

* Hoernecke R, Doenicke A. Perioperative Enzymtherapie. Eine sinnvolle Ergflnzung zur postoperativen Schmerztherapie? (Perioperative enzyme therapy. A significant supplement to postoperative pain therapy?)[http://www. mrw. interscience, wiley. com/cochrane/clcentral/articles/862/CN- 00098862/frame.html]

* Kullich W, Schwann H. ZIRKULIERENDE IMMUNKOMPLEXE UND DAS KOMPLEMENTFRAGMENT IC3B BEI CHRONISCHER POLYARTHRITIS WAHREND EINER 12 MONATIGEN THERAPIE MIT ORALEN ENZYMEN IM VERGLEICH ZU ORALEM GOLD. (Changes of circulating immune complexes and inactivated C3b in rheumatoid arthritis during 12 months therapy with oral enzymes compared to oral gold). [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/694/CN-00194694/frame.html]

* Dittmar F-W, Weissenbacher E.R. Therapy of adnexitis - enhancement of the basic antibiotic therapy with hydrolytic enzymes. [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/146/CN- 00195146/frame, html]

* Baumuller M. DER EINSATZ VON HYDROLYTISCHEN ENZYMEN BEI STUMPFE WEICHTEILVERLETZUNGEN UND SPRUNGGELENKTSDISTORSIONEN. EINE KLINISCHE DOPPELBLINDSTUDIE. (The application of hydrolytic enzymes in blunt wounds to the soft tissue and distortion of the ankle joint - A double-blind clinical trial). [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/548/CN-00351548/frame.html]

* Rammer E, Friedrich F. Enzymtherapie zur Behandlung der Mastopathie. Eine randomisierte doppelblinde klinische Studie. (Enzyme therapy in treatment of mastopathy. A randomized double-blind clinical study), [http://www.mrw. interscience. wiley.com/cochrane/clcentral/articles/832/CN-00124832/fra me. html]

* Rahn H-D, Kilic M. DIE WIRKSAMKEIT HYDROLYTISCHER ENZYME IN DER TRAU MATO LOGIE. ERGEBNISSE NACH 2 PROSPEKTIVEN RANDOMISIERTEN DOPPELBLINDSTUDIEN (The effectiveness of a hydrolytic enzyme in traumatology. The results of two prospective, randomized, double-blind studies.) [http://www.mrw.interscience.wiley.com/cochrane/clcentral/articles/887/CN-00195887/frame.html]

Pubmed

* Mukhin IV, Nikolenko Vlu. Experimental systemic enzyme therapy of gouty and primary glomerulonephritis. Eksp Klin Farmakol. 2003 Jul-Aug;66(4):32-5. [http://www.ncbi.nlm.nih.gov/pubmed/14558349]

* Neverov VA, Klimov AV. The pathogenetic basis for and clinical use of systemic enzyme therapy in traumatology and orthopedics. Vestn Khir Im I I Grek. 1999;158(l):41-4. [http://www.ncbi.nlm.nih.gov/pubmed/10491833]

* Remezov AP, Knorring Glu. Systemic enzyme therapy as a method for potentiation of the effect of antibacterial agents. Antibiot Khimioter. 2003;48(3):30-3. [http://www.ncbi.nlm.nih.gov/pubmed/12914119]

* Heyll U, Munnich U, Senger V. Proteolytic enzymes as an alternative in comparison with nonsteroidal antiinflammatory drugs (NSAID) in the treatment of degenerative and inflammatory rheumatic disease: systematic review. Med Klin (Munich). 2003 Nov 15;98(11):609-15. [http://www.ncbi.nlm.nih.gov/pubmed/14631536]

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* Minaev SV, Ibragimov OR, ZelenskiT VA, Minaeva NV.Enzyme therapy of patients with pyo-inflammatory disease of maxillofacial area. Voen Med Zh. 2007 Nov;328(ll):25-7, 96. [http://www.ncbi.nlm.nih.gov/pubmed/18306709].

* Minaev SV, Obozin VS, Barnash GM, Obedin AN.The influence of enzymes on adhesive processes in the abdominal cavity. EurJ PediatrSurg. 2009 Dec;19(6):380-3. doi: 10.1055/s-0029-1241847.[ http://www.ncbi.nlm.nih.gov/pubmed/19866411]

* Tets GV, Artemenko NK, Zaslavskaia NV, Artemenko KL, Knorring Glu, Tets VV, Sternin lul. Effect of exogenic proteolytic enzymes on transfer of plasmid genes in mixed bacterial biofilms. Antibiot Khimioter. 2009;54(9- 10):3-5. [http://www.ncbi.nlm.nih.gov/pubmed/20415254]

* Dubovskaia LA, Guseva MR, Gorbunova ED, Gorbunov AV, Kazinskaia NV. Systemic enzyme therapy in the treatment of children with lower orbital wall fractures. Vestn Oftalmol. 2006 Nov-Dec;122(6):20-3, [http://www.ncbi.nlm.nih.gov/pubmed/17217196]

* Sternin lul, Safonov LV, Levando VA.Systemic poly-enzyme therapy in prophylaxis of venous blood circulation disorder in the lower limbs in modern sport. Voen Med Zh. 2008 May;329(5):42-5. [http://www.ncbi.nlm.nih.gov/pubmed/18589703]

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